Dee Wallace portrays Donna Trenton, a mother trapped in a car with her son while being stalked by a rabid dog.
Danny Pintauro plays Tad Trenton, the young son of Donna who is in danger when their car breaks down in the grips of a rabid St. Bernard.
Daniel Hugh Kelly embodies the character of Vic Trenton, Donna's husband, who is unaware of the peril his family faces.
Christopher Stone takes on the role of Steve Kemp, a character whose subplot intertwines with the main story involving the Trenton family.
Ed Lauter plays Joe Camber, the owner of Cujo, whose unwitting neglect leads to the dog's rabid state.
Kaiulani Lee portrays Charity Camber, Joe Camber's wife, who becomes entangled in the events set in motion by Cujo.
Billy Jayne takes on the character of Brett Camber, the young son of the Camber family who has a brief encounter with the protagonists.
Mills Watson embodies Gary Pervier, a character whose actions have consequences that impact the unfolding events involving Cujo.
Sandy Ward plays the role of Bannerman, a character who becomes involved in the escalating danger caused by Cujo.
Jerry Hardin portrays the character of Masen, a figure who plays a part in the unfolding events surrounding Cujo and the Trenton family.
Merritt Olsen takes on the role of the Professor, a character whose expertise may hold the key to resolving the crisis presented by Cujo.
Frank Welker provides the uncredited voice of Cujo, the menacing St. Bernard whose transformation into a threat sets the movie's events in motion.
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