Bobcat Goldthwait plays Fred P. Chaney, a down-on-his-luck man who partners with a talking horse named Don in a horse racing venture.
John Candy provides the voice for Don The Horse, a unique and talkative equine companion who helps Fred navigate the world of horse racing.
Dabney Coleman portrays Walter Sawyer, a skeptical and wealthy businessman who becomes involved in Fred and Don's horse racing scheme.
Virginia Madsen takes on the role of Allison Rowe, a supportive love interest of Fred who becomes entangled in the horse racing antics.
Cindy Pickett plays Victoria Peyton, a sophisticated and wealthy socialite who adds a touch of glamour to the horse racing world in the film.
Jim Metzler embodies the character Boyd Osborne, a competitive and ambitious rival of Fred in the high-stakes world of horse racing.
Gilbert Gottfried takes on the role of The Dentist, an eccentric and colorful character who adds comedic flair to the horse racing narrative.
James Hong portrays Boss, a shrewd and influential figure in the horse racing industry who has a significant impact on Fred and Don's journey.
Burgess Meredith appears as Don's Dad, a wise and seasoned horse with a special connection to his son Don, playing a key role in the film.
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