Laura Dern plays the dual role of Nikki Grace / Susan Blue, the main character who gets involved in a mysterious film production.
Jeremy Irons portrays Kingsley Stewart, the director in the film within the film in Inland Empire.
Justin Theroux takes on the roles of Devon Berk / Billy Side, characters with connections to the dark side of the film industry.
Harry Dean Stanton appears as Freddie Howard, a character who adds layers of intrigue to the complex storyline of Inland Empire.
Karolina Gruszka plays the Lost Girl, a mysterious character who interacts with the main protagonist in unusual ways.
Peter J. Lucas portrays Piotrek Krol, a supporting character whose presence contributes to the bizarre atmosphere of Inland Empire.
Krzysztof Majchrzak appears as the Phantom, a figure shrouded in mystery and symbolic significance within the narrative.
Jan Hencz is Janek, a character whose role intertwines with the surreal nature of the storytelling in Inland Empire.
Grace Zabriskie portrays Visitor #1, a character who enhances the enigmatic and unsettling atmosphere of the film.
William H. Macy appears as Announcer, a voice that adds an additional layer of intrigue and uncertainty to the proceedings in Inland Empire.
Ian Abercrombie plays Henry the Butler, a supporting character who contributes to the mysterious and dreamlike elements of the story.
Amanda Foreman portrays Tracy, a character who plays a role in the complex and interconnected narrative of Inland Empire.
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