Mel Gibson portrays Martin Riggs, a skilled and occasionally reckless detective known for his unconventional methods and troubled past.
Danny Glover plays Roger Murtaugh, a seasoned and sensible detective who often finds himself partnered with the unpredictable Riggs.
Joe Pesci assumes the role of Leo Getz, a fast-talking informant who frequently assists Riggs and Murtaugh with their investigations.
Rene Russo takes on the character of Lorna Cole, a sharp-witted internal affairs officer who becomes romantically involved with Riggs.
Stuart Wilson portrays Jack Travis, a former police officer turned arms dealer who becomes the main antagonist in the film.
Steve Kahan plays Captain Ed Murphy, the commanding officer of Riggs and Murtaugh who oversees their often turbulent investigations.
Mary Ellen Trainor appears as Stephanie Woods, a police officer and love interest for one of the characters in the film.
Darlene Love portrays Trish Murtaugh, the supportive and caring wife of Roger Murtaugh.
Traci Wolfe plays Rianne Murtaugh, the daughter of Roger Murtaugh who finds herself in peril during the events of the film.
Ebonie Smith assumes the role of Carrie Murtaugh, the youngest daughter of Roger Murtaugh who adds moments of familial warmth to the storyline.
Damon Hines plays Nick Murtaugh, the wise-beyond-his-years son of Roger Murtaugh who gets caught up in the dangerous situations of the film.
Thomas A. Geas appears as the Man at Hamburger Stand, a minor character who contributes to a memorable scene in the movie.
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