Jack Johnson portrays Will Robinson, the youngest member of the Robinson family who is known for his intelligence and resourcefulness.
Gary Oldman takes on the role of Dr. Zachary Smith, a cunning and manipulative saboteur who becomes the Robinsons' unexpected companion.
William Hurt plays Prof. John Robinson, the patriarch of the Robinson family who is a brilliant scientist and dedicated father.
Mimi Rogers portrays Dr. Maureen Robinson, the matriarch of the family who is a skilled engineer and loving mother.
Lacey Chabert brings to life Penny Robinson, the middle child of the Robinson family who is known for her empathy and creativity.
Matt LeBlanc plays Maj. Don West, a skilled pilot and brave member of the Jupiter 2 mission.
Heather Graham portrays Dr. Judy Robinson, the eldest daughter of the Robinson family who is a talented doctor and strong-willed individual.
Jared Harris appears as Older Will Robinson, portraying an older version of the character who provides guidance to his younger self.
Mark Goddard takes on the role of General, a military leader who plays a key part in the mission to colonize a new planet.
Lennie James portrays Jeb Walker, a supporting character in the film who is involved in the mission alongside the Robinson family.
Marta Kristen appears as Reporter #1, a minor character in the film who contributes to the storyline through her reporting.
June Lockhart plays Principal Cartwright, a character who has a brief but memorable role in the movie.
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