Jack Nicholson plays Charley Partanna, a hitman for the Prizzi family who falls in love with a woman that complicates his loyalty.
Kathleen Turner portrays Irene Walker, a con artist who becomes involved with Charley Partanna and the Prizzi family.
Robert Loggia takes on the role of Eduardo Prizzi, a key figure in the Prizzi crime family.
John Randolph plays Angelo 'Pop' Partanna, Charley's father and a high-ranking member within the Prizzi family.
William Hickey portrays Don Corrado Prizzi, the elderly and respected head of the Prizzi crime family.
Lee Richardson plays Dominic Prizzi, a significant member of the Prizzi family.
Michael Lombard portrays Rosario Filargi 'Finlay', a character intertwined with the Prizzi family.
Anjelica Huston takes on the role of Maerose Prizzi, a complex character within the Prizzi family dynamics.
Lawrence Tierney portrays Lt. Hanley, a law enforcement character involved in the world of organized crime.
CCH Pounder plays Peaches Altamont, a character connected to the intricate web of relationships in the film.
Ann Selepegno portrays Amalia Prizzi, a member of the Prizzi family caught up in the internal conflicts.
Vic Polizos plays Phil Vittimizzare, a character involved in the criminal activities within the Prizzi family.
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