Robert Carradine portrays Lewis Skolnick, one of the main nerds who leads the group in their escapades.
Larry B. Scott plays Lamar Latrelle, a nerdy fraternity brother who adds humor to the group dynamic.
Timothy Busfield takes on the role of Arnold Poindexter, a lovable nerd known for his artistic talents.
Courtney Thorne-Smith appears as Sunny Carstairs, a character who interacts with the nerds during their adventures.
Anthony Edwards portrays Gilbert Lowell, a nerdy student who brings his unique skills to the group.
Curtis Armstrong embodies Dudley 'Booger' Dawson, a quirky and comedic member of the nerd fraternity.
Andrew Cassese plays Harold Wormser, a nerdy member of the group who contributes to their schemes.
Donald Gibb portrays Ogre, a recurring character known for his intimidating presence.
Bradley Whitford plays Roger, a character intertwined with the nerd's escapades during their trip to Florida.
Ed Lauter takes on the role of Buzz Mussinger, a character who adds conflict to the nerds' adventures.
Barry Sobel appears as Stewart, a character who interacts with the nerds throughout their comedic journey.
Tom Hodges portrays Tiny, a character who plays a part in the nerds' comedic escapades in the film.
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