Cast of Throw Momma from the Train

Danny DeVito portrays Owen, a aspiring writer who gets caught up in a murder plot with Larry Donner.

Billy Crystal plays Larry Donner, a writing instructor who finds himself entangled in a murder scheme with Owen.

Kim Greist takes on the role of Beth Ryan, Larry's ex-wife who becomes a key figure in the unfolding events.

Anne Ramsey brings Mrs. Lift to life, Owen's overbearing and demanding mother who plays a significant role in the story.

Kate Mulgrew plays Margaret, Larry's girlfriend who gets caught up in the chaotic events surrounding Owen and Larry.

Branford Marsalis portrays Lester, a character with a connection to the main plot of the movie.

Rob Reiner plays Joel, a police detective involved in the investigation surrounding the mysterious events within the story.

Bruce Kirby takes on the role of DeBenedetto, a character who plays a part in the unfolding events of the movie.

Annie Ross portrays Mrs. Hazeltine, a character intertwined in the complex web of relationships within the story.

Oprah Winfrey makes a cameo appearance as Herself in a memorable moment within the movie.

Raye Birk plays Pinsky, a character who contributes to the humorous and suspenseful tone of the movie.

Olivia Brown portrays Ms. Gladstone, a character who adds depth to the narrative through her interactions with the main cast.