Chevy Chase plays the role of Clark Griswold, the well-meaning but accident-prone patriarch of the Griswold family.
Beverly D'Angelo portrays Ellen Griswold, Clark's wife who tries to keep the family together amidst the Vegas chaos.
Randy Quaid appears as Cousin Eddie, the eccentric and slightly clueless relative of the Griswold family.
Ethan Embry takes on the role of Russell 'Rusty' Griswold, the teenage son who gets caught up in his family's Vegas antics.
Marisol Nichols plays Audrey Griswold, the Griswold's daughter who experiences her own adventures in Las Vegas.
Miriam Flynn portrays Cousin Catherine, another quirky member of the extended Griswold family.
Shae D'Lyn appears as Cousin Vicki, known for her wild and unpredictable behavior.
Wayne Newton makes a special appearance as Himself, adding to the Vegas flair of the film.
Wallace Shawn plays Marty, a character who becomes entangled in the Griswold family's Vegas escapades.
Siegfried Fischbacher portrays Siegfried, one half of the famous duo Siegfried & Roy who are featured in the film.
Roy Horn appears as Roy, the other half of the iconic act Siegfried & Roy.
Sid Caesar plays Mr. Ellis, a character who crosses paths with the Griswold family during their Vegas vacation.
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