John Candy portrays the title character Harry Crumb, a clumsy and inept detective from a long line of detectives.
Jeffrey Jones plays Eliot Draisen, a wealthy businessman who hires Harry Crumb to investigate the kidnapping of his wife.
Annie Potts takes on the role of Helen Downing, the kidnapped wife of Eliot Draisen, whose disappearance sets the plot in motion.
Tim Thomerson portrays Vince Barnes, a suspicious character who becomes a suspect in the kidnapping case that Harry Crumb is investigating.
Barry Corbin plays P.J. Downing, the father of the kidnapped woman Helen Downing, whose gruff demeanor adds a layer of complexity to the story.
Shawnee Smith takes on the role of Nikki Downing, the daughter of Helen and P.J. Downing, who gets caught up in the chaos surrounding her mother's disappearance.
Valri Bromfield portrays Detective Casey, a no-nonsense police officer who crosses paths with Harry Crumb during his investigation.
Doug Steckler plays Dwayne, a character who gets entangled in Harry Crumb's antics as he tries to crack the case.
Renée Coleman takes on the role of Jennifer Downing, a family member involved in the kidnapping mystery that Harry Crumb is tasked to solve.
Tamsin Kelsey portrays Marie, a character who becomes part of the unfolding story as Harry Crumb delves deeper into the case.
Joe Flaherty plays the Doorman, a minor character who interacts briefly with Harry Crumb during his investigation.
Michele Goodger portrays Mrs. MacIntyre, a character involved in the storyline of Who's Harry Crumb? and its central mystery.
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