Cast of Lady Dynamite

Maria Bamford plays the lead role of Maria Bamford, a fictionalized version of herself. Maria is a quirky and charismatic comedian who battles with bipolar disorder, anxiety, and depression. Throughout the series, Maria navigates her personal and professional life, showcasing her unique brand of humor and resilience.

Ana Gasteyer portrays Karen Grisham, a close friend of Maria's. Karen is a successful and ambitious businesswoman who serves as a source of support and comic relief for Maria. Ana's comedic timing and wit bring Karen to life, adding depth to the character's dynamic with Maria.

Dean Cain makes a guest appearance on the show, playing a character whose name hasn't been specified. Dean's charm and acting abilities shine through in his portrayal, creating an intriguing and memorable presence on screen.

Sarah Silverman guest stars in Lady Dynamite, assuming a character whose name hasn't been revealed. Sarah's comedic talent and sharp wit add an extra layer of humor to the series, showcasing her versatility as an actress.

Jenny Slate takes on the role of Karen Grisham, a character that shares the same name as Ana Gasteyer's character. Jenny brings her unique comedic style to the show, infusing the character with her own charm and quirkiness.

Mira Sorvino joins the cast as a character whose name hasn't been disclosed. Mira's talent and on-screen presence enhance the show, leaving a lasting impression with her portrayal.

Patton Oswalt portrays Patton Cop, a character within the series. Patton's comedic skills and charisma shine through, bringing humor and heart to his role.

Brandon Routh plays the character of Jack in Lady Dynamite. Jack serves as an important figure in Maria's life, bringing an element of romance and camaraderie to the series. Brandon's acting prowess and charm contribute to the overall chemistry between his character and Maria.