Cast of Boys on the Side

Whoopi Goldberg plays Jane Deluca, a no-nonsense, strong-willed nightclub singer who is HIV positive.

Mary-Louise Parker portrays Robin, a free-spirited real estate agent running from an abusive relationship.

Drew Barrymore takes on the role of Holly Pulchik-Lincoln, a young woman looking for a fresh start after experiencing heartbreak and loss.

Matthew McConaughey appears as Abe Lincoln, Holly's kind-hearted husband who tragically passes away.

James Remar plays Alex, a charming police officer who becomes involved in the women's journey.

Billy Wirth portrays Nick, a musician and Holly's ex-boyfriend struggling with addiction.

Jude Ciccolella appears as Jerry, a friend of Jane's who helps the women when they are in need.

Dennis Boutsikaris takes on the role of Massarelli, Holly's lawyer who provides support during a difficult time.

Estelle Parsons portrays Louise, Holly's conservative mother who disapproves of her lifestyle choices.

Amy Aquino appears as Anna, a hospice nurse who provides care and comfort to Jane.

Lori Alan plays the Girl with Attitude, a character encountered by the women on their journey.

Anita Gillette portrays Elaine, a friend of Abe who offers support to the group.