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Allison Janney portrays Sue Buttons, the main character of the movie.

Mila Kunis plays the role of Nancy, a character involved in the central plot of the movie.

Regina Hall portrays Detective Cam Harris, a key character in the investigation of the movie's events.

Awkwafina takes on the role of Mina, a character with a significant impact on the story.

Wanda Sykes plays the character Rita and brings her unique comedic talent to the film.

Ellen Barkin portrays Debbie, a character with connections to the central plot.

Matthew Modine takes on the role of Karl Buttons, a character with a crucial role in the movie.

Jimmi Simpson plays Petey Buttons, a character who adds complexity to the storyline.