Robert De Niro plays Sam 'Ace' Rothstein, a casino executive and mob associate tasked with running the Tangiers Casino.
Sharon Stone portrays Ginger McKenna, a former prostitute who becomes Ace's wife but has a troubled and tumultuous relationship with him.
Joe Pesci takes on the role of Nicky Santoro, a mobster and childhood friend of Ace sent to protect the casino's operations.
James Woods plays Lester Diamond, Ginger's former lover who re-enters her life, causing further turmoil.
Don Rickles portrays Billy Sherbert, the casino manager who tries to keep operations running smoothly amid the chaos.
Alan King appears as Andy Stone, a mob boss and casino executive who becomes entangled in the criminal activities at the casino.
Kevin Pollak portrays Phillip Green, a corrupt businessman with ties to the casino who eventually faces legal troubles.
L.Q. Jones plays Pat Webb, a county commissioner who becomes involved in the casino's operations and legal battles.
Dick Smothers portrays Senator, a political figure who is manipulated by the mob to serve their interests.
Frank Vincent takes on the role of Frank Marino, a mob enforcer who causes trouble and conflict within the criminal organization.
John Bloom plays Don Ward, a casino executive who becomes a pawn in the power struggles and deceit at the Tangiers.
Pasquale Cajano portrays Remo Gaggi, a mob boss overseeing the casino's operations and dealing with internal conflicts.
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