Cast of Isle of Dogs

Bryan Cranston voices Chief, a stray dog who becomes a reluctant leader and protector in the story.

Koyu Rankin voices Atari Kobayashi, a young boy on a mission to find his lost dog Spots on Trash Island.

Bob Balaban voices King, one of the dogs accompanying Chief and helping Atari on his quest.

Edward Norton voices Rex, one of the dogs banished to Trash Island who assists Atari.

Bill Murray voices Boss, a dog with a carefree attitude who is part of Atari's search party.

Jeff Goldblum voices Duke, a dog with a philosophical outlook on events in the movie.

Kunichi Nomura voices Mayor Kobayashi, the authoritarian leader of Megasaki City.

Fisher Stevens voices Scrap, a dog with a resourceful nature that aids in the group's escape.

Akira Takayama voices Major Domo, the loyal servant and right-hand to Mayor Kobayashi.

Greta Gerwig voices Tracy Walker, an American exchange student who uncovers a conspiracy in Megasaki City.

Ken Watanabe voices the Head Surgeon, a pivotal character in the medical scenes of Isle of Dogs.

Frances McDormand voices Interpreter Nelson, a crucial figure translating important messages throughout the film.