Mel Gibson plays Martin Riggs, a reckless and skilled detective known for his unconventional methods.
Danny Glover portrays Roger Murtaugh, a seasoned detective and family man who often finds himself paired with Riggs.
Joe Pesci takes on the role of Leo Getz, a fast-talking and quirky informant who aids Riggs and Murtaugh in their investigation.
Joss Ackland is Arjen Rudd, a corrupt South African diplomat and the main antagonist in the film.
Derrick O'Connor portrays Pieter Vorstedt, Rudd's ruthless henchman who poses a significant threat to the detectives.
Patsy Kensit plays Rika Van Den Haas, a key witness in the case who forms a bond with Riggs.
Darlene Love is Trish Murtaugh, Roger Murtaugh's supportive and understanding wife.
Steve Kahan portrays Captain Ed Murphy, the commanding officer of Riggs and Murtaugh who provides guidance and leadership.
Mark Rolston plays Hans, one of Rudd's henchmen who engages in violent encounters with the detectives.
Jenette Goldstein portrays Meagan Shapiro, a federal investigator who assists Riggs and Murtaugh in their case.
Dean Norris is Tim Cavanaugh, a police officer who works alongside Riggs and Murtaugh in their pursuit of justice.
Juney Smith takes on the role of Tom Wyler, a police officer who supports Riggs and Murtaugh on their mission.
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