Julia Roberts portrays Julianne Potter, a food critic who realizes she is in love with her best friend Michael just before his wedding.
Dermot Mulroney plays Michael O'Neal, Julianne's best friend who is about to get married to his girlfriend Kimberly.
Cameron Diaz takes on the role of Kimberly Wallace, Michael's wealthy and charming fiancée.
Rupert Everett portrays George Downes, Julianne's gay friend who poses as her fiancé to make Michael jealous.
Christopher Masterson plays Scotty O'Neal, Michael's younger brother who looks up to Julianne.
M. Emmet Walsh portrays Joe O'Neal, Michael and Scotty's father.
Philip Bosco plays Walter Wallace, Kimberly's father.
Rachel Griffiths portrays Samantha Newhouse, Julianne's friend attending the wedding.
Carrie Preston plays Mandy Newhouse, Samantha's sister and a bridesmaid.
Susan Sullivan portrays Isabelle Wallace, Kimberly's mother.
Raci Alexander is Title Sequence Performer #1 in the movie.
Jennifer Garrett plays Title Sequence Performer #2 in the movie.
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