Kevin Kline portrays Paden, a charming drifter with a mysterious past who joins forces with the main group of protagonists.
Scott Glenn plays Emmett, a stoic cowboy on a mission to save his family's land from corrupt forces in Silverado.
Danny Glover embodies Malachi 'Mal' Johnson, a skilled gunslinger with a sense of justice and a troubled history.
Kevin Costner takes on the role of Jake, Emmett's reckless younger brother who adds a layer of unpredictability to the group.
Brian Dennehy is Cobb, the ruthless and power-hungry sheriff of Turley, whose actions set events in motion for the main characters.
Rosanna Arquette embodies Hannah, a spirited saloon owner in Silverado who forms a bond with some of the protagonists.
John Cleese portrays Sheriff John T. Langston, the bumbling and ineffectual lawman of Silverado who provides some comic relief.
Linda Hunt plays Stella, the tough and resilient owner of the local boarding house who assists the main group during their stay.
Jeff Goldblum is Slick, a sly gambler and outlaw who may or may not have his own agenda when dealing with the group.
Brad Leland appears as Trooper, a member of Cobb's posse who finds himself caught between following orders and questioning authority.
Marvin J. McIntyre plays Clerk, a minor character in the town of Silverado who has a brief interaction with some of the main protagonists.
Sheb Wooley is the Cavalry Sergeant, a seasoned military man who crosses paths with the main group during their journey.
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