Mike Myers portrays the lead character, Charlie Mackenzie, a commitment-phobic poet who becomes suspicious that his new girlfriend may be a notorious axe murderer.
Nancy Travis plays Harriet Michaels, Charlie's love interest who may or may not have a dark secret.
Anthony LaPaglia takes on the role of Tony Giardino, Charlie's best friend and a police detective who gets involved in the investigation.
Amanda Plummer portrays Rose Michaels, Harriet's quirky sister who adds an eccentric element to the story.
Brenda Fricker plays May Mackenzie, Charlie's overbearing and protective mother.
Charles Grodin appears as the Commandeered Driver, a minor character in the film.
Phil Hartman portrays Ranger John 'Vicky' Johnson, adding a comedic touch to the story.
Debi Mazar plays Susan, a supporting character in the film.
Steven Wright appears as the Pilot, a brief role in the movie.
Michael Richards portrays the Newspaper reporter, a minor role in the film.
Mike Hagerty plays the Obituary Writer, another minor character in the story.
Alan Arkin has an uncredited role as Tony's Boss / Precinct Capt. in the movie.
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