Cast of Spider-Man

Tobey Maguire portrays Spider-Man / Peter Parker, a high school student who gains superhuman abilities after being bitten by a genetically-altered spider.

Willem Dafoe plays Green Goblin / Norman Osborn, a scientist and business tycoon who becomes Spider-Man's archenemy after a failed experiment leads to his transformation.

Kirsten Dunst takes on the role of Mary Jane Watson, Peter Parker's love interest and a friend from his high school days.

James Franco portrays Harry Osborn, Peter Parker's best friend who undergoes a complicated relationship with both Peter and his father, Norman Osborn.

Cliff Robertson plays Ben Parker, Peter Parker's loving uncle who imparts valuable life lessons before tragically meeting his end.

Rosemary Harris embodies May Parker, Peter Parker's caring aunt who becomes a source of strength and wisdom in his life.

J.K. Simmons stars as J. Jonah Jameson, the irascible editor-in-chief of the Daily Bugle who is constantly at odds with Spider-Man.

Joe Manganiello takes on the role of Flash Thompson, a high school jock who bullies Peter Parker but later undergoes character development.

Gerry Becker portrays Maximilian Fargas, a wealthy businessman who becomes entangled in the conflicts between Spider-Man and his enemies.

Bill Nunn plays Joseph 'Robbie' Robertson, a principled editor at the Daily Bugle who often serves as a moral compass in the face of J. Jonah Jameson's antics.

Jack Betts embodies Henry Balkan, a character in the film who becomes involved in the events surrounding Spider-Man and his adversaries.

Stanley Anderson portrays General Slocum, a military figure who plays a role in the overarching conflicts that Spider-Man faces in the movie.