Dolly Parton plays the lead role of Shirlee Kenyon, a kind-hearted woman who unexpectedly finds success as a radio talk show host.
James Woods portrays Jack Russell, Shirlee's love interest and a journalist who helps her navigate the world of media and fame.
Griffin Dunne takes on the character of Alan Riegert, Shirlee's supportive friend who stands by her through her journey in radio.
Michael Madsen plays Steve, a radio station employee who becomes a loyal friend to Shirlee and supports her show.
Deirdre O'Connell portrays Lily, a fellow radio host who becomes a close confidante of Shirlee during her rise to fame.
John Sayles is Guy Girardi, a radio station manager who initially underestimates Shirlee but later recognizes her talent and potential.
Teri Hatcher plays Janice, a colleague of Shirlee's at the radio station who forms a strong bond with her as they work together.
Spalding Gray portrays Dr. Erdman, a psychiatrist who appears on Shirlee's show and provides comedic moments with his unconventional advice.
Jerry Orbach is Milo Jacoby, a seasoned radio personality who offers guidance and wisdom to Shirlee as she navigates her new career.
Philip Bosco plays Gene Perlman, a senior executive at the radio station who oversees Shirlee's show and becomes impressed by her success.
Charles Fleischer portrays Tony, a quirky character who works behind the scenes at the radio station and adds humor to the story.
Keith MacKechnie is Gordon, a supportive friend of Shirlee's who encourages her to pursue her dreams and provides comic relief.
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