Shailene Woodley portrays Hazel Grace Lancaster, a sixteen-year-old girl diagnosed with cancer, who meets and falls in love with Augustus Waters.
Ansel Elgort plays Augustus Waters, a charismatic and charming cancer survivor who forms a deep connection with Hazel Grace Lancaster.
Nat Wolff takes on the role of Isaac, a friend of Hazel and Augustus who is also battling cancer and undergoes a breakup during the story.
Laura Dern stars as Frannie Lancaster, Hazel's caring and supportive mother who tries to help her daughter navigate the challenges of her illness.
Sam Trammell plays Michael Lancaster, Hazel's father, who shares a strong bond with his daughter and supports her throughout her journey.
Willem Dafoe takes on the role of Peter van Houten, a reclusive and enigmatic author whom Hazel and Augustus seek out for answers about his book.
Lotte Verbeek portrays Lidewij Vliegenthart, Peter van Houten's assistant who helps arrange the meeting between the author and Hazel and Augustus.
Mike Birbiglia plays the character Patrick, a support group leader who guides Hazel, Augustus, and other young cancer patients through their challenges.
Ana Dela Cruz appears as Dr. Maria, one of the medical professionals involved in treating and supporting Hazel and other young cancer patients.
Randy Kovitz plays Dr. Simmons, another medical staff member who plays a part in Hazel's treatment and care during her battle with cancer.
Emily Peachey takes on the role of Monica, a friend of Hazel who is part of her support system as she navigates the challenges of her illness.
David Whalen portrays Gus' Dad, Augustus Waters' father, who is shown to be supportive of his son and plays a role in his life and journey.
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