Christopher Guest plays Nigel Tufnel, the lead guitarist of the band and known for his eccentric personality and obsession with his amplifiers.
Michael McKean portrays David St. Hubbins, the lead vocalist and rhythm guitarist of Spinal Tap, who tries to hold the band together amidst various challenges.
Harry Shearer takes on the role of Derek Smalls, the bassist of Spinal Tap, known for his laid-back demeanor and deep thoughts on the music industry.
Rob Reiner stars as Marty DiBergi, a filmmaker who follows Spinal Tap on their tour and documents their ups and downs in the mockumentary.
June Chadwick plays Jeanine Pettibone, the wife of David St. Hubbins who becomes entangled in the band's drama during their chaotic tour.
Bruno Kirby portrays Tommy Pischedda, the limo driver who gets caught up in Spinal Tap's outlandish antics and rockstar lifestyle.
Ed Begley Jr. takes on the role of John 'Stumpy' Pepys, the original drummer of Spinal Tap who meets a tragic yet humorous fate early in the film.
Fran Drescher stars as Bobbi Flekman, the band's tough and no-nonsense record executive who juggles the chaos that comes with managing Spinal Tap.
Dana Carvey appears as the Mime Waiter, a hilarious character who adds to the absurdity of the film during a memorable scene in a restaurant.
Sandy Helberg portrays Angelo DiMentibelio, the band's incompetent and quirky manager who struggles to keep Spinal Tap on track during their tour.
Billy Crystal makes a cameo as Morty the Mime, a mime who entertains the band with his unique performance style in a scene filled with comedic moments.
Paul Benedict plays Tucker 'Smitty' Brown, the bewildered and unassuming director who tries to capture Spinal Tap's essence in an interview segment of the mockumentary.
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