Alexis Bledel portrays Winnie Foster, a young girl who discovers the Tuck family and their immortal secret.
William Hurt plays Angus Tuck, the patriarch of the Tuck family, who bears the weight of their immortality.
Sissy Spacek takes on the role of Mae Tuck, Angus's wife, who is motherly and protective of her family's secret.
Jonathan Jackson is Jesse Tuck, the youngest of the Tuck family, who falls in love with Winnie Foster.
Scott Bairstow acts as Miles Tuck, the elder son of the Tuck family, who is haunted by his past.
Ben Kingsley embodies the Man in the Yellow Suit, a mysterious figure aiming to discover and exploit the Tuck family's secret.
Amy Irving plays Mother Foster, Winnie Foster's strict and concerned mother.
Victor Garber is Robert Foster, Winnie's father, who joins in the search for her when she goes missing.
Kosha Engler portrays Miles' Wife, who is part of Miles Tuck's backstory and his life before immortality.
Richard Pilcher plays the Constable, who is involved in the investigation of the Tucks' secret.
Bradley Coryell acts as Lead Mill Boy, one of the local boys who interacts with the Tuck family.
John Badila plays the Baker, a minor character who appears in the town's setting of the film.
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