Cast of What's Up, Doc?

Barbra Streisand plays Judy Maxwell, a vivacious and carefree young woman who inadvertently gets entangled in a chaotic series of events.

Ryan O'Neal portrays Howard Bannister, a shy and mild-mannered musicologist who finds himself caught up in a whirlwind of confusion and misunderstandings.

Madeline Kahn brings Eunice Burns to life, a stylish and dramatic woman entangled in the madcap antics unfolding around her.

Kenneth Mars plays Hugh Simon, an uptight and comically befuddled character swept up in the chaos of the film's zany events.

Austin Pendleton portrays Frederick Larrabee, a quirky and neurotic character caught in the middle of the film's escalating mix-ups and mayhem.

Michael Murphy takes on the role of Mr. Smith, a suave and sophisticated man whose presence adds to the confusion and excitement of the film.

Philip Roth plays Mr. Jones, a mysterious and enigmatic figure whose actions contribute to the comedic chaos unfolding in the movie.

Sorrell Booke portrays Harry, a character entangled in the unpredictable and farcical situations that arise throughout the film.

Stefan Gierasch brings Fritz to life, a minor character caught up in the absurdities and misunderstandings that propel the movie's plot.

Mabel Albertson plays Mrs. Van Hoskins, a character whose presence adds an extra layer of humor and confusion to the film's narrative.

Liam Dunn appears as Judge Maxwell, a supporting character who becomes embroiled in the chaotic events unfolding throughout the movie.

John Hillerman takes on the role of the Hotel Manager, a minor character caught up in the comedic whirlwind that sweeps through the movie.