William Hurt plays Tom Grunick, a handsome but not very bright newscaster who starts off as a sportscaster and then transitions into a news anchor.
Albert Brooks portrays Aaron Altman, a seasoned news reporter who is intelligent and talented but struggles with his on-air charisma.
Holly Hunter brings to life Jane Craig, a talented and dedicated producer who is passionate about journalism and constantly striving for excellence.
Robert Prosky plays Ernie Merriman, the gruff but lovable managing editor of the news network who navigates the challenges of running a newsroom.
Lois Chiles portrays Jennifer Mack, a glamorous network executive who is both ambitious and strategic in her approach to advancing her career.
Joan Cusack plays Blair Litton, a quirky and enthusiastic production assistant who provides comic relief in the newsroom.
Peter Hackes portrays Paul Moore, a seasoned news reporter who is highly respected within the industry for his integrity and professionalism.
Christian Clemenson plays Bobby, a young and eager news writer who is trying to make his mark in the competitive world of broadcast journalism.
Jack Nicholson portrays Bill Rorich, a veteran network anchor with a charismatic and authoritative presence that commands attention.
Robert Katims plays Martin Klein, a network executive who is ambitious and driven, with a keen eye for talent and potential in the newsroom.
Ed Wheeler portrays George Wein, a senior news producer who brings a wealth of experience and knowledge to the newsroom.
Stephen Mendillo plays Gerald Grunick, Tom Grunick's father, who is supportive of his son but also has high expectations for his success.
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