Desperately Seeking Susan Cast

Madonna plays Susan, a free-spirited and enigmatic character whose mysterious life captivates others in the story.

Rosanna Arquette portrays Roberta Glass, a bored suburban housewife who becomes obsessed with the intriguing Susan.

Aidan Quinn takes on the role of Dez, a charismatic young man who gets caught up in the antics surrounding Susan and Roberta.

Mark Blum plays Gary Glass, Roberta's husband who becomes entangled in the chaotic events set in motion by Susan's presence.

Robert Joy portrays Jim, a key character who becomes involved in the unfolding events alongside Roberta and Susan.

Laurie Metcalf embodies Leslie Glass, a supporting character caught up in the whirlwind of mistaken identities and unforeseen consequences.

Anna Thomson takes on the role of Crystal, a colorful character whose interactions with Susan and Roberta drive the narrative forward.

Will Patton portrays Wayne Nolan, a character whose path crosses with Susan's, leading to unexpected turns of fate.

Steven Wright plays Larry Stillman D.D.S., a dentist who plays a minor yet memorable role in the comedic chaos of the film.

John Turturro portrays Ray, a character whose actions set off a chain of events that impact the lives of those around him.

Giancarlo Esposito appears as the Street Vendor, a brief but notable character encountered by the main cast during their escapades.

Richard Hell takes on the role of Bruce Meeker, adding a unique presence to the eclectic mix of characters populating the film.