Jason Schwartzman portrays Albert Markovski, an environmentalist who seeks the help of existential detectives to solve a series of coincidences.
Isabelle Huppert plays Caterine Vauban, a nihilistic philosopher who challenges the characters' perceptions and methods of the existential detectives.
Dustin Hoffman appears as Bernard Jaffe, one half of the husband-and-wife team of existential detectives investigating the life of the protagonist.
Lily Tomlin depicts Vivian Jaffe, Bernard's partner in their existential detective agency and a sharp-witted investigator.
Jude Law plays Brad Stand, a smooth-talking corporate executive whose life intertwines with the other characters in unexpected ways.
Mark Wahlberg takes on the role of Tommy Corn, a firefighter with a profound disdain for petroleum who joins the protagonists in their quest for meaning.
Naomi Watts portrays Dawn Campbell, Brad's seemingly superficial girlfriend whose experiences spur a significant personal transformation.
Isla Fisher plays Heather, a chirpy Huckabees store employee whose connection to the other characters adds to the film's exploration of identity.
Sydney Zarp appears as Cricket Hooten, a young girl involved in the existential detectives' investigation.
Jonah Hill plays Bret Hooten, Cricket's brother who also becomes embroiled in the unfolding existential narrative.
Darlene Hunt takes the role of Darlene, an employee at Huckabees with her own insights contributing to the central themes of the film.
Kevin Dunn depicts Marty, an executive at the Huckabees corporation who faces his own existential questions.
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