Charlie Sheen portrays Rick Vaughn, a talented but unpredictable pitcher known for his powerful arm and signature glasses.
Tom Berenger plays Jake Taylor, the aging catcher and team leader who struggles to keep the team motivated.
Corbin Bernsen embodies Roger Dorn, the former player turned team owner who still has a love for the game.
Dennis Haysbert is Pedro Cerrano, the power-hitting batter with a quirky religious superstition involving voodoo and Jobu.
James Gammon takes on the role of Lou Brown, the gruff but lovable manager who tries to whip the team into shape.
Omar Epps portrays Willie Mays Hayes, the speedy outfielder with a flair for the dramatic and a talent for base stealing.
Eric Bruskotter plays Rube Baker, the nervous young catcher trying to prove himself on the team.
Takaaki Ishibashi portrays Isuro Tanaka, the crafty and mysterious pitcher from Japan who joins the team.
Alison Doody is Flannery, the sports psychologist who tries to help the players with their mental game and personal issues.
Michelle Burke plays Nikki Reese, the new love interest who creates tension among the players.
David Keith is Jack Parkman, the arrogant and talented catcher who joins the team with a chip on his shoulder.
Margaret Whitton portrays Rachel Phelps, the former owner who still has a stake in the team and causes trouble for the players.
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