Eddie Murphy plays multiple roles including Sherman Klump, a kind-hearted professor; Buddy Love, his mischievous alter ego; and Lance Perkins, a smooth-talking character.
Janet Jackson portrays Denise Gaines, a love interest of Sherman Klump who is supportive and caring.
Larry Miller plays Dean Richmond, who oversees the university where Sherman works.
John Ales plays Jason, a character involved in the story with Sherman.
Richard Gant portrays Denise's Father, a concerned parent in the film.
Anna Maria Horsford plays Denise's Mother, contributing to the family dynamics.
Melinda McGraw plays Leanne Guilford, a character in the story.
Jamal Mixon plays Ernie Klump, Jr., a member of the Klump family.
Gabriel Williams portrays Issac, a character in the film.
Chris Elliott plays the Restaurant Manager, who interacts with the main characters.
Duffy Taylor plays the Restaurant Trainee, contributing to the scenes set in the restaurant.
Earl Boen portrays Dr. Knoll, a character involved in Sherman's life.
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