Tye Sheridan plays Wade Watts, also known as Parzival, a teenager who competes in a virtual reality game to find a hidden Easter egg.
Olivia Cooke portrays Samantha Cook, known as Artemis, a skilled player in the OASIS and a love interest of Wade Watts.
Ben Mendelsohn takes on the role of Nolan Sorrento, the antagonist and head of the company trying to control the OASIS.
Lena Waithe plays Helen Harris, also known as Aech, a close friend of Wade who is also a competitive player in the OASIS.
T.J. Miller provides the voice for i-R0k, a bounty hunter who tries to capture Parzival and his friends.
Simon Pegg plays Ogden Morrow, a co-creator of the OASIS who plays a significant role in the story.
Mark Rylance portrays James Halliday, the creator of the OASIS whose legacy drives the quest to find his Easter egg.
Philip Zhao plays Zhou, also known as Sho, a player who teams up with Wade and Artemis.
Win Morisaki portrays Toshiro, known as Daito, a friend of Wade and fellow competitor in the OASIS.
Hannah John-Kamen plays F'Nale Zandor, an important player in the fight for control over the OASIS.
Ralph Ineson plays Rick, a character who interacts with the main players in the OASIS.
Susan Lynch portrays Alice, a character connected to the protagonist's journey in the film.
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