Robert Carradine plays Lewis Skolnick, one of the main nerds who helps lead the fraternity in their battles against the jocks.
Anthony Edwards portrays Gilbert Lowell, a sensitive nerd who becomes a key member of the fraternity.
Timothy Busfield takes on the role of Arnold Poindexter, a lovable nerd who showcases his talents in the fraternity.
Curtis Armstrong plays 'Booger' Dawson, a crude but endearing member of the nerds who provides comic relief.
Larry B. Scott portrays Lamar Latrell, a stylish and confident nerd who stands out among the group.
Andrew Cassese plays Harold Wormser, a young nerd who finds friendship and confidence within the fraternity.
Brian Tochi takes on the role of Toshiro Takashi, a nerd with a strong sense of loyalty and humor.
Julia Montgomery portrays Betty Childs, a sorority girl who becomes romantically involved with one of the nerds.
Michelle Meyrink plays Judy, a quirky and intelligent member of the sorority who befriends the nerds.
Ted McGinley portrays Stan Gable, a jock and antagonist to the nerds who faces off against the fraternity.
Matt Salinger plays Danny Burke, a fraternity brother who supports the nerds in their endeavors.
Donald Gibb portrays Fred 'The Ogre' Palowakski, a boisterous and physically imposing jock who clashes with the nerds.
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