Chevy Chase plays Emmett Fitz-Hume, one of the bumbling government employees who unwittingly becomes part of a CIA mission.
Dan Aykroyd portrays Austin Millbarge, the other fumbling government employee who gets caught up in a CIA operation alongside Fitz-Hume.
Steve Forrest takes on the role of General Sline, a key figure in the CIA operation involving the two unlikely spies.
Donna Dixon appears as Karen Boyer, a character who becomes intertwined with the antics of Fitz-Hume and Millbarge during the mission.
Bruce Davison portrays Ruby, a supporting character in the film who plays a role in the comedic escapades of the main characters.
Terry Gilliam plays Dr. Imhaus, a character with a significant role in the plot as part of the mission that Fitz-Hume and Millbarge get involved in.
Frank Oz takes on the role of Test Monitor, a character who adds to the humor and challenges faced by the main characters.
Vanessa Angel appears as a Russian Rocket Crewperson, adding to the international intrigue and chaos in which the protagonists find themselves.
Bernie Casey plays Colonel Rhumbus, a character who interacts with the main cast members as part of the mission storyline.
Charles McKeown portrays Jerry Hadley, a character who contributes to the comedic situations encountered by the protagonists.
William Prince takes on the role of Keyes, a character connected to the mission unfolding throughout the film.
Bob Hope appears as Self, making a special appearance in the film, adding to the star-studded cast of Spies Like Us.
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