Peter Weller portrays the titular character, Buckaroo Banzai, a brilliant scientist, rock musician, and adventurer.
John Lithgow plays Lord John Whorfin, the main antagonist of the film who seeks to control the 8th dimension.
Ellen Barkin takes on the role of Penny Priddy, a character with a mysterious connection to Buckaroo Banzai.
Jeff Goldblum embodies New Jersey, a member of Buckaroo's team known for his intelligence and quirky personality.
Christopher Lloyd portrays John Bigboote, a member of the evil Red Lectroids who opposes Buckaroo Banzai.
Lewis Smith plays Perfect Tommy, a skilled member of Buckaroo's team known for his cool demeanor.
Rosalind Cash portrays John Emdall, a key member of Buckaroo's support team with a no-nonsense attitude.
Robert Ito takes on the role of Professor Hikita, Buckaroo Banzai's mentor and scientific advisor.
Pepe Serna plays Reno Nevada, one of the loyal members of Buckaroo's crew who provides support in their adventures.
Ronald Lacey portrays President Widmark, a government official dealing with the mysterious events surrounding Buckaroo Banzai.
Matt Clark plays the Secretary of Defense, a government official involved in the unfolding events tied to Buckaroo Banzai's actions.
Clancy Brown embodies the character of Rawhide, a key member of Buckaroo's team with a tough and no-nonsense attitude.
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