Shawnee Smith plays Meg Penny, a young woman who becomes entangled in the dangerous situation involving the Blob.
Kevin Dillon portrays Brian Flagg, a rebellious teenager who joins forces with Meg to defeat the Blob.
Donovan Leitch takes on the role of Paul Taylor, one of the town's residents trying to survive the Blob's attacks.
Jeffrey DeMunn plays Sheriff Herb Geller, the local law enforcement officer dealing with the Blob crisis.
Candy Clark portrays Fran Hewitt, a community member caught up in the chaos caused by the Blob.
Joe Seneca is seen as Dr. Meddows, a scientist attempting to understand and stop the Blob's destructive rampage.
Del Close plays Reverend Meeker, a religious figure witnessing the Blob's wrath in the town.
Paul McCrane portrays Deputy Bill Briggs, assisting Sheriff Geller in combating the Blob.
Sharon Spelman appears as Mrs. Penny, a character with connections to Meg Penny in the story.
Beau Billingslea is Moss Woodley, another resident of the town affected by the Blob's attacks.
Art LaFleur takes on the roles of both Pharmacist and Mr. Penny, adding depth to the narrative.
Ricky Paull Goldin is Scott Jeske, a character facing the terror brought by the Blob.
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