Harrison Ford plays Dr. Richard Kimble, a man wrongfully convicted of his wife's murder who must evade the law while searching for the real killer.
Tommy Lee Jones portrays Deputy Marshal Samuel Gerard, a relentless lawman leading the pursuit to capture the fugitive, Dr. Richard Kimble.
Joe Pantoliano takes on the role of Deputy Marshal Cosmo Renfro, a member of Gerard's team involved in the hunt for Dr. Richard Kimble.
Jeroen Krabbé portrays Dr. Charles Nichols, a key figure in the mystery surrounding the murder of Dr. Kimble's wife.
Daniel Roebuck plays Biggs, a prison guard connected to events in Dr. Kimble's past.
L. Scott Caldwell appears as Poole, a pivotal character in Dr. Kimble's quest for justice.
Tom Wood takes on the role of Newman, a federal agent involved in the investigation into Dr. Kimble's case.
Ron Dean portrays Detective Kelly, a law enforcement officer pursuing Dr. Kimble as a suspect in his wife's murder.
Joseph F. Kosala plays Detective Rosetti, another member of the law enforcement team tracking Dr. Kimble.
Andreas Katsulas appears as Frederick Sykes, a key player in the events tied to Dr. Kimble's wrongful conviction.
Sela Ward portrays Helen Kimble, the murdered wife of Dr. Richard Kimble whose death sets off the chain of events in the movie.
Julianne Moore appears as Anne Eastman, a medical professional who becomes involved with Dr. Kimble during his quest for justice.
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