Nigel Hawthorne portrays George III, the King of England who grapples with mental illness during his reign.
Helen Mirren takes on the role of Queen Charlotte, the devoted wife of King George III, who stands by him during his illness.
Ian Holm plays Willis, the King's devoted and unconventional physician who tries to cure his mental illness.
Anthony Calf appears as Fitzroy, a member of the government who is involved in the political machinations surrounding the King.
Amanda Donohoe portrays Lady Pembroke, a member of the royal court who interacts with the King and Queen.
Rupert Graves takes on the role of Greville, a character involved in the political intrigue of the time.
Geoffrey Palmer appears as Warren, a member of the government who deals with the challenges of the King's illness.
Julian Wadham plays Pitt, a key political figure who grapples with the consequences of the King's illness on the government.
John Wood portrays Thurlow, another important political figure who navigates the challenges faced by the government.
Rupert Everett takes on the role of the Prince of Wales, the heir to the throne who is affected by his father's illness.
Jim Carter appears as Fox, a historical figure involved in the political landscape of the time.
Roger Hammond portrays Baker, a character who plays a role in the events surrounding King George III's reign.
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