This Is 40 Cast
The cast of This Is 40 including popularity data. Data for April 15, 2025.
Paul Rudd
as Pete

Paul Rudd plays the character Pete.

#6
Most popular actor on This Is 40
4,467 Wikipedia views yesterday
Leslie Mann
as Debbie

Leslie Mann portrays the character Debbie.

#11
Most popular actor on This Is 40
2,509 Wikipedia views yesterday
John Lithgow
as Oliver

John Lithgow takes on the role of Oliver.

#1
Most popular actor on This Is 40
18,925 Wikipedia views yesterday
Megan Fox
as Desi

Megan Fox appears as the character Desi.

#4
Most popular actor on This Is 40
6,577 Wikipedia views yesterday
Maude Apatow
as Sadie

Maude Apatow brings the character Sadie to life.

#12
Most popular actor on This Is 40
2,283 Wikipedia views yesterday
Iris Apatow
as Charlotte

Iris Apatow portrays the character Charlotte.

#16
Most popular actor on This Is 40
1,327 Wikipedia views yesterday
Chris O'Dowd
as Ronnie

Chris O'Dowd plays the character Ronnie.

#3
Most popular actor on This Is 40
10,707 Wikipedia views yesterday
Jason Segel
as Jason

Jason Segel portrays the character Jason.

#8
Most popular actor on This Is 40
3,306 Wikipedia views yesterday
Melissa McCarthy
as Catherine
#10
Most popular actor on This Is 40
3,018 Wikipedia views yesterday
Graham Parker
as Graham Parker
Albert Brooks
as Larry
#14
Most popular actor on This Is 40
1,790 Wikipedia views yesterday
Lena Dunham
as Cat
#9
Most popular actor on This Is 40
3,156 Wikipedia views yesterday
Annie Mumolo
as Barb
#21
Most popular actor on This Is 40
331 Wikipedia views yesterday
Robert Smigel
as Barry
#18
Most popular actor on This Is 40
472 Wikipedia views yesterday
Charlyne Yi
as Jodi
#15
Most popular actor on This Is 40
1,349 Wikipedia views yesterday
Lisa Darr
as Clair
#24
Most popular actor on This Is 40
44 Wikipedia views yesterday
Billie Joe Armstrong
as Billie Joe Armstrong
#2
Most popular actor on This Is 40
17,293 Wikipedia views yesterday
Michael Ian Black
as Accountant
#17
Most popular actor on This Is 40
691 Wikipedia views yesterday
Wyatt Russell
as Flirty Hockey Player
#5
Most popular actor on This Is 40
6,185 Wikipedia views yesterday
Tom Yi
as Charlotte's Teacher
Tim Bagley
as Dr. Pellegrino
#20
Most popular actor on This Is 40
401 Wikipedia views yesterday
Ava Sambora
as Wendy
Megan Grano
as School Playdate Parent
#28
Most popular actor on This Is 40
4 Wikipedia views yesterday
D.A. Sandoval
as Older Pregnant Parent
Derek Basco
as Room Service Waiter
Nicol Paone
as E.R. Nurse
#26
Most popular actor on This Is 40
17 Wikipedia views yesterday
Lynne Alana Delaney
as Disturbed Restaurant Patron (uncredited)
Katia Kieling
as BBQ Guest (uncredited)
Bill Hader
as Desi's Store Pickup (uncredited)
#7
Most popular actor on This Is 40
3,640 Wikipedia views yesterday
Tom Everett
as Pete's Doctor
#23
Most popular actor on This Is 40
161 Wikipedia views yesterday
Tatum O'Neal
as Realtor
#13
Most popular actor on This Is 40
1,818 Wikipedia views yesterday
Ryan Adams
as Ryan Adams
Jessica Lee
as Party Guest #1 (uncredited)
#27
Most popular actor on This Is 40
11 Wikipedia views yesterday
Rebekka Johnson
as Gyno Nurse
#25
Most popular actor on This Is 40
18 Wikipedia views yesterday
Johnny Pemberton
as Room Service Waiter
#19
Most popular actor on This Is 40
415 Wikipedia views yesterday
Dan Bakkedahl
as Dentist
#22
Most popular actor on This Is 40
256 Wikipedia views yesterday
For the best insights and data about This Is 40, visit our main This Is 40 page.