Bill Murray portrays Bob Wiley, a charming but overly dependent psychiatric patient who becomes attached to his therapist, Dr. Leo Marvin.
Richard Dreyfuss stars as Dr. Leo Marvin, a successful psychiatrist whose life is turned upside down when his obsessive patient, Bob Wiley, follows him on vacation.
Julie Hagerty plays Fay Marvin, the supportive and patient wife of Dr. Leo Marvin who tries to handle the chaos caused by Bob's intrusion into their lives.
Charlie Korsmo portrays Sigmund 'Siggy' Marvin, the young son of Dr. Leo and Fay Marvin, who forms a close bond with Bob despite his father's disdain.
Kathryn Erbe takes on the role of Anna Marvin, the teenage daughter of Dr. Leo and Fay Marvin, who also gets caught up in the mayhem caused by Bob.
Tom Aldredge appears as Mr. Guttman, a friendly elderly man whom Bob befriends during his antics in the small town.
Susan Willis plays Mrs. Guttman, the wife of Mr. Guttman, who also gets entangled in the humorous situations created by Bob.
Roger Bowen appears as Phil, a resident of the town who interacts with Bob and adds to the comedic elements of the film.
Fran Brill portrays Lily Marvin, the sister-in-law of Dr. Leo Marvin, whose presence adds to the family dynamics in the film.
Brian Reddy takes on the role of Carswell Fensterwald, M.D., a colleague of Dr. Leo Marvin who witnesses the chaos caused by Bob's unorthodox methods.
Doris Belack plays Dr. Catherine Tomsky, a professional acquaintance of Dr. Leo Marvin who is skeptical of Bob's unorthodox approach to therapy.
Melinda Mullins appears as Marie Grady, a local resident who interacts with Bob during his eventful stay in the town.
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