Painkiller (TV) Cast
The cast of Painkiller. Updated on October 5, 2025.
23 actors
Uzo Aduba
as Edie Flowers (6 episodes)

Uzo Aduba portrays Edie Flowers, a key figure involved in investigating the impact of OxyContin.

Matthew Broderick
as Richard Sackler (6 episodes)

Matthew Broderick plays Richard Sackler, a member of the Sackler family who owned Purdue Pharma.

Taylor Kitsch
as Glen Kryger (6 episodes)

Taylor Kitsch takes on the role of Glen Kryger, whose life is deeply affected by the opioid epidemic.

Dina Shihabi
as Britt Hufford (6 episodes)

Dina Shihabi stars as Britt Hufford, a character linked to the unfolding crisis.

West Duchovny
as Shannon Schaeffer (6 episodes)

West Duchovny plays Shannon Schaeffer, who is involved in the opioid storyline.

John Rothman
as Mortimer Sackler (6 episodes)

John Rothman portrays Mortimer Sackler, another influential member of the Sackler family.

Clark Gregg
as Arthur Sackler (6 episodes)

Clark Gregg acts as Arthur Sackler, a pivotal figure in the Sackler family.

Jack Mulhern
as Tyler Kryger (6 episodes)

Jack Mulhern plays Tyler Kryger, who is connected to Glen Kryger.

Sam Anderson
as Raymond Sackler (6 episodes)

Sam Anderson features as Raymond Sackler, part of the family at the center of the series.

Tyler Ritter
as US Attorney John Brownlee (6 episodes)

Tyler Ritter portrays US Attorney John Brownlee, involved in legal proceedings related to the epidemic.

Ana Cruz Kayne
as Brianna Ortiz (6 episodes)

Ana Cruz Kayne plays Brianna Ortiz, a character integrated into the opioid narrative.

John Ales
as Dr. Gregory Fitzgibbons (6 episodes)

John Ales features as Dr. Gregory Fitzgibbons, intertwined with the medical aspects of the crisis.

Carolina Bartczak
as Lily Kryger (6 episodes)

Carolina Bartczak brings life to the character of Lily Kryger in Painkiller. Lily Kryger is an essential character in the show, and Bartczak's performance adds depth to the role. Bartczak's portrayal of Lily Kryger is commendable and keeps the audience engaged.

Ron Lea
as Bill Havens (6 episodes)
Kyle Gatehouse
as Riggs (2 episodes)
Daniel Kash
as Stanley (1 episode)
Stuart Hughes
as Tony (2 episodes)
Yasmin Lau
as Hoop Earrings (1 episode)
Caylie Mcrae
as Coyle's Receptionist (1 episode)
Kathryn Bellamy
as Tanya (1 episode)
Lexie Galante
as Young Rep #1 (1 episode)
Sarah Curd
as U of C Recruit #3 (1 episode)
Rosie Callaghan
as Richard's Maid (1 episode)
For the best insights and data about the TV show Painkiller, visit our main Painkiller page.