Joaquin Phoenix portrays Larry 'Doc' Sportello, a hippie private investigator caught up in a complex web of mystery and intrigue.
Josh Brolin plays Lt. Det. Christian F. 'Bigfoot' Bjornsen, a no-nonsense LAPD detective who has a complicated relationship with Doc Sportello.
Owen Wilson portrays Coy Harlingen, a musician who gets entangled in Doc Sportello's investigation.
Katherine Waterston plays Shasta Fay Hepworth, an enigmatic ex-girlfriend of Doc Sportello who seeks his help.
Reese Witherspoon portrays Deputy D.A. Penny Kimball, a district attorney who becomes involved in Doc's case.
Benicio del Toro plays Sauncho Smilax, a maritime lawyer and confidant of Doc Sportello.
Jena Malone portrays Hope Harlingen, the wife of musician Coy Harlingen, who seeks Doc's assistance.
Joanna Newsom plays Sortilège, a narrator-like figure who is a friend and confidante of Doc Sportello.
Jordan Christian Hearn plays Denis, a minor character connected to the shady dealings in the film.
Hong Chau portrays Jade, a massage parlor worker involved in the mystery surrounding Doc Sportello.
Jeannie Berlin plays Aunt Reet, a family member of one of the characters drawn into the investigation.
Maya Rudolph portrays Petunia Leeway, a minor character who provides comic relief in the movie.
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