Dennis Quaid portrays Lt. Tuck Pendleton, a pilot who volunteers to be miniaturized and injected into a rabbit as part of a scientific experiment.
Martin Short plays Jack Putter, a hypochondriac who becomes unwittingly involved in the experiment when Tuck's pod is injected into him.
Meg Ryan stars as Lydia Maxwell, Tuck's journalist ex-girlfriend who gets caught up in the adventure.
Kevin McCarthy appears as Victor Eugene Scrimshaw, a ruthless industrialist trying to get his hands on the technology behind miniaturization.
Fiona Lewis portrays Dr. Margaret Canker, a scientist involved in the experiment with Tuck and Jack.
Vernon Wells plays Mr. Igoe, one of Scrimshaw's henchmen who cause trouble for the protagonists.
Robert Picardo appears as The Cowboy, a mysterious individual encountered by Tuck inside Jack's body.
Dick Miller plays Cab Driver, a character who unwittingly becomes part of the chaotic journey inside Jack's body.
Wendy Schaal portrays Wendy, Jack's colleague who helps him during his bizarre predicament.
Harold Sylvester plays Pete Blanchard, a friend of Jack who gets caught up in the adventure.
William Schallert appears as Dr. Greenbush, a scientist involved in the miniaturization experiment.
Henry Gibson portrays Mr. Wormwood, another character involved in the machinations surrounding miniaturization technology.
Our free email delivers the daily top 10 TV shows and top 10 movies directly to your inbox. Stay ahead of the trends. Sign up below.