Ellen DeGeneres plays Martha Alston, the lead character who gets involved with the wrong man.
Bill Pullman portrays Whitman Crawford, a love interest of Martha who may not be who he seems.
Joan Cusack takes on the role of Inga Gunther, a quirky and supportive friend of Martha's.
Dean Stockwell appears as Jack Tramonte, a character with a mysterious past.
Joan Plowright plays Mrs. Crawford, a pivotal figure in the story.
John Livingston portrays Walter, a character whose role unfolds as the story progresses.
Hope Davis takes on the role of Annie, a friend of Martha who offers support.
Ellen Cleghorne plays Jane, another friend in Martha's circle.
Christine Cattell portrays Nancy Culpepper, a character who plays a part in Martha's journey.
Robert Goulet appears as Dick Braxton, adding to the ensemble cast of Mr. Wrong.
Michael George is the uncredited Musician in the film, contributing to the soundtrack.
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