Matt Damon plays Mike McDermott, a law student and skilled poker player who navigates the dangerous world of underground gambling.
Edward Norton portrays Lester 'Worm' Murphy, Mike's childhood friend and a troublemaker who draws Mike back into the risky world of poker.
John Turturro takes on the role of Joey Knish, a seasoned poker player who serves as a mentor figure to Mike.
Gretchen Mol plays Jo, Mike's girlfriend who becomes entangled in his gambling pursuits.
John Malkovich portrays Teddy KGB, a Russian mobster and seasoned poker player who becomes a formidable opponent for Mike.
Famke Janssen plays Petra, Mike's ex-girlfriend who works as a bartender and stands by him despite their past.
Martin Landau portrays Abe Petrovsky, a seasoned poker player and friend of Mike who offers guidance and wisdom.
Michael Rispoli plays Grama, a fellow poker player who is part of the underground poker scene.
Goran Visnjic portrays Maurice, a poker player who becomes involved in Mike's circle.
Mal Z. Lawrence plays Irving, a character in the world of underground poker.
Paul Cicero portrays the Russian Thug, a menacing figure in the underground poker world.
Ray Iannicelli plays Kenny, a character involved in the high-stakes poker games that Mike participates in.
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