Julie Kavner plays Dottie Ingels, a stand-up comic who grapples with the challenges of balancing her career and family life.
Samantha Mathis portrays Erica Ingels, Dottie's older daughter who struggles to cope with her mother's growing success.
Gaby Hoffmann takes on the role of Opal Ingels, Dottie's younger daughter who also deals with the changes brought about by her mother's career.
Carrie Fisher appears as Claudia Curtis, a successful comedian who becomes a mentor to Dottie as she navigates the comedy scene.
Dan Aykroyd plays Arnold Moss, a comedy club owner who offers Dottie a platform for her talent but also introduces her to the challenges of show business.
Bob Nelson takes on the role of Ed, a fellow comedian who befriends Dottie and provides comedic support.
Marita Geraghty portrays Mia Jablon, a friend of Dottie who offers her guidance and perspective on the entertainment industry.
Welker White appears as Lynn, a member of Dottie's circle who provides insight and support during her journey.
Caroline Aaron plays Martha Ingels, Dottie's sister who offers familial support and comedic relief throughout the film.
Kathy Najimy takes on the role of Angela, a friend who stands by Dottie through her ups and downs in the comedy world.
Danny Zorn portrays Jordan Strang, a love interest who complicates Dottie's personal and professional life.
Renée Lippin appears as Arlene, a character who adds a humorous and dramatic element to Dottie's journey.
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