Christopher Guest plays Corky St. Clair, an overly enthusiastic and flamboyant director who takes charge of the community theater production.
Eugene Levy portrays Dr. Allan Pearl, a quirky and outlandish dentist who gets involved in the musical production organized by Corky St. Clair.
Fred Willard plays Ron Albertson, the enthusiastic and clueless travel agent who dreams of being a star in the local show.
Catherine O'Hara portrays Sheila Albertson, Ron's supportive wife who becomes part of the musical production in the small town.
Michael Hitchcock appears as Steve Stark, a councilman in the town who becomes involved in Corky St. Clair's theatrical project.
Larry Miller portrays Glenn Welsch, the Mayor of the town who oversees the events and developments surrounding the community theater production.
Parker Posey plays Libby Mae Brown, a spirited and quirky actress who becomes part of the musical production led by Corky St. Clair.
Bob Balaban portrays Lloyd Miller, a reserved and practical character who also gets entangled in the theatrical endeavors of the small town.
Don Lake appears as Phil Burgess, the Blaine Historian who participates in the local show prepared by Corky St. Clair.
David Cross plays the UFO Expert in the small town, adding an eccentric and comedic element to the dynamics of the community theater production.
Paul Dooley portrays the UFO Abductee in the movie, contributing to the odd and quirky elements that shape the storyline of Waiting for Guffman.
Lewis Arquette appears as Clifford Wooley, adding his unique presence to the ensemble and contributing to the eccentric charm of the movie.
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