Grimm

David Giuntoli portrays the character of Nick Burkhardt, a detective and a Grimm. As a Grimm, Nick has the ability to see Wesen, mythical creatures that inhabit the world. He becomes a balance-keeper between the human and Wesen world, using his abilities to protect innocent lives from dangerous creatures.

Silas Weir Mitchell plays the role of Monroe, a Blutbad Wesen. Monroe befriends Nick and becomes his trusted ally and advisor. He helps Nick understand the Wesen world and assists him in various cases. Throughout the series, Monroe's expertise and compassion make him an invaluable asset to the Grimm.

Russell Hornsby portrays the character of Hank Griffin, Nick's partner and a homicide detective. Hank initially struggles to accept the existence of Wesen but eventually becomes an integral part of Nick's investigations. He provides Nick with support and backup, often putting his own life at risk to solve cases alongside his Grimm partner.

Sasha Roiz plays the role of Sean Renard, a royal bastard and captain of the Portland Police Department's North Precinct. Renard is a complex character with his own hidden agenda. He becomes entangled in both the human and Wesen worlds, often using his influence to further his own interests while maintaining his position of power.

Reggie Lee portrays the character of Drew Wu, a police sergeant. Wu starts off as a skeptic but later discovers the truth about the Wesen. He becomes a loyal friend to Nick, aiding him in investigations and offering assistance whenever possible.

Bree Turner plays the role of Rosalee Calvert, a Fuchsbau Wesen and a Fuchsbau apothecary. Rosalee joins the main cast in the second season and becomes an important member of the Grimm team. She uses her knowledge of herbs and remedies to help Nick and his allies fight against dangerous Wesen threats.

Claire Coffee portrays the character of Adalind Schade, a Hexenbiest. Adalind is a powerful sorceress who often antagonizes Nick and his allies. Over the course of the series, her character undergoes significant development, with her motives and alliances frequently shifting.

Julianne Christie plays the role of Nancy Keary, a Wesen control officer who works for the Wesen Council. Nancy is introduced in later seasons and plays a vital role in maintaining order within the Wesen community.