The Borgias

Jeremy Irons portrays the role of Rodrigo Borgia, later known as Pope Alexander VI. Rodrigo is a cunning and ambitious man who becomes the head of the Borgia family and eventually ascends to the papacy. He is known for his political maneuvering and his desire to consolidate power for his family.

François Arnaud plays the role of Cesare Borgia, the eldest son of Rodrigo Borgia. Cesare is a skilled military strategist and a key figure in the family's quest for power. He is devoted to his family and will stop at nothing to protect their interests.

Holliday Grainger portrays Lucrezia Borgia, the daughter of Rodrigo Borgia. Lucrezia is initially used as a political pawn, but as the series progresses, she becomes a shrewd and influential figure in her own right. She is caught between her family's ambitions and her own desires for love and personal fulfillment.

Joanne Whalley plays the role of Vanozza Cattaneo, the mistress of Rodrigo Borgia and the mother of his children. Vanozza is a strong and independent woman who wields considerable influence behind the scenes. She navigates the complexities of her relationship with Rodrigo while ensuring the well-being of her children.

Colm Feore portrays Giuliano Della Rovere, a powerful cardinal and political rival of the Borgia family. Giuliano is determined to take down the Borgias and claims moral superiority over them. He becomes a formidable opponent, constantly plotting to undermine their influence.

Peter Sullivan plays the role of Cardinal Ascanio Sforza, a member of the College of Cardinals and an ally of the Borgia family. He is a skilled diplomat and helps Rodrigo navigate the intricacies of Vatican politics. Cardinal Sforza is often torn between his loyalty to the Borgias and his own ambitions.

Sean Harris portrays the character of Micheletto, a loyal and deadly assassin in the service of Cesare Borgia. Micheletto is a complex and enigmatic figure, willing to do whatever it takes to protect Cesare and advance the Borgia family's interests.

Lotte Verbeek plays the role of Giulia Farnese, a mistress of Rodrigo Borgia and a key player in the family's network of alliances. Giulia is intelligent, charming, and manipulative, using her influence to further her own interests while maintaining her position within the Borgia circle.