Dick Van Dyke portrays Rev. Clayton Brooks, a charismatic and determined leader who orchestrates the town's initiative to quit smoking.
Pippa Scott plays Natalie Brooks, the supportive and caring wife of Rev. Clayton Brooks, who stands by him through the challenges faced during the town's no-smoking campaign.
Tom Poston portrays Mr. Stopworth, a quirky and comedic character caught up in the chaos of the town's smoking cessation efforts.
Edward Everett Horton takes on the role of Hiram C. Greyson, adding a touch of eccentricity to the mix of characters involved in the town's ambitious endeavor.
Bob Elliott is seen in multiple roles as Hugh Upson, David Chetley, and Sandy Van Andy, adding a comedic element to the film through his diverse characters.
Vincent Gardenia plays Mayor Wappler, a politician navigating the challenges arising from the town's smoking cessation efforts while trying to maintain order.
Barnard Hughes portrays Dr. Proctor, a character involved in the medical aspects of the town's anti-smoking campaign, adding a professional perspective to the narrative.
Graham Jarvis appears as Amos Bush, a resident of the town whose reactions and experiences are intertwined with the larger context of the smoking cessation challenge.
Jean Stapleton plays Mrs. Wappler, adding a touch of community life and interpersonal dynamics to the unfolding events in the town's quirky anti-smoking campaign.
Paul Benedict appears as the Zen Buddhist character, offering a different perspective and philosophy amidst the chaos surrounding the town's smoking cessation efforts.
Judith Lowry portrays Odie Turman, adding her unique charm and presence to the diverse cast of characters involved in the town's humorous quest to quit smoking.
Bob Newhart takes on the role of Merwin Wren, contributing his signature comedic style to the film's ensemble cast and the unfolding narrative of the town's anti-smoking campaign.
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