Michael Keaton portrays John Kelly, also known as Johnny Dangerously, a kind-hearted man who gets pulled into a life of organized crime.
Peter Boyle plays Jocko Dundee, Johnny's loyal friend and confidant who helps him navigate the criminal underworld.
Griffin Dunne takes on the role of Tommy Kelly, Johnny's younger brother who inadvertently gets involved in his criminal activities.
Marilu Henner portrays Lil, Johnny's love interest who stands by his side through his tumultuous journey.
Joe Piscopo plays Danny Vermin, Johnny's rival gangster who constantly tries to outsmart him.
Maureen Stapleton takes on the role of Ma Kelly, Johnny's loving and supportive mother who is unaware of his criminal endeavors.
Dom DeLuise appears as The Pope, a humorous character who provides comedic relief throughout the film.
Danny DeVito portrays Burr, a cunning gangster who crosses paths with Johnny in the world of crime.
Glynnis O'Connor plays Sally, a character involved in Johnny's life who adds emotional depth to the story.
Vincent Schiavelli appears as a character who contributes to the colorful underworld that Johnny navigates.
Ray Walston portrays Gabe, the Newsstand Vendor, a minor character who adds charm to the film.
Sudie Bond takes on the role of Mary Margaret Catherine Dineen, a character who plays a small but significant part in Johnny's story.
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